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PRAGMATIC RANDOMIZED TRIAL EVALUATING PRE-OPERATIVE AQUEOUS AND ANTISEPTIC SKIN SOLUTION IN OPEN FRACTURES

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The Aqueous-PREP trial will enroll at least 1,540 patients with open fractures, and evaluate if aqueous pre-operative antiseptic skin preparation with 10% povidone-iodine is more effective than 4% chlorhexidine at preventing surgical site infections and unplanned fracture-related reoperations.

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PRAGMATIC RANDOMIZED TRIAL EVALUATING PRE-OPERATIVE ALCOHOL SKIN SOLUTIONS IN FRACTURED EXTREMITIES

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The PREPARE trial will enroll at least 7,820 patients with open and closed lower extremity and pelvic fractures (6,280 closed fractures; 1,540 open fractures) and evaluate if alcohol-based pre-operative antiseptic skin preparation with iodine-povacrylex (0.7% free iodine) is more effective than 2% chlorhexidine gluconate at preventing surgical site infections and unplanned fracture-related reoperations.

investigator meeting pictures